TCO-conjugated chondroitin sulfate (TCO-CS) forms a bioorthogonal complex through covalent attachment of trans-cyclooctene groups, blending chondroitin's therapeutic benefits with TCO's rapid click chemistry reactivity.
Glycan Name
Chondroitin sulfate
Glycan Structure
The glycan structure of chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) composed of repeating disaccharide units. Each unit consists of:
N-acetyl-D-galactosamine (GalNAc) (β1→4 linked)
D-glucuronic acid (GlcA) (β1→104 linked)
Source
Chemical synthesis
Functional Group
TCO
Form
Solid or powder
Purity
≥95%
Impurities
No visible impurities to the naked eye.
Solubility
This product is soluble in most organic solvents, such as DCM, DMF, DMSO, and THF, and exhibits excellent solubility in water.
Identity
Confirmed by NMR.
Applications
Chondroitin sulfate-trans-cyclooctene can be used for its potential to enable bioorthogonal click chemistry applications through strain-promoted cycloaddition reactions.
Publications
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Publications
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