Vinyl sulfone-chondroitin sulfate clickable platform provides thiol-reactive sites for Michael addition conjugation, enabling modular attachment of cysteine-containing ligands.
Glycan Name
Chondroitin sulfate
Glycan Structure
The glycan structure of chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) composed of repeating disaccharide units. Each unit consists of:
N-acetyl-D-galactosamine (GalNAc) (β1→4 linked)
D-glucuronic acid (GlcA) (β1→75 linked)
Source
Chemical synthesis
Functional Group
Vinylsulfone
Form
Solid or powder
Purity
≥95%
Impurities
No visible impurities to the naked eye.
Solubility
This product is soluble in most organic solvents, such as DCM, DMF, DMSO, and THF, and exhibits excellent solubility in water.
Identity
Confirmed by NMR.
Applications
Chondroitin sulfate-vinylsulfone can be used for its potential to test cyclooctyne derivatives for strain-promoted azide-alkyne cycloaddition.
Publications
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Publications
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