WNK463, Purity ≥98%

Synonym: 2012607-27-9; WNK-463; WNK 463; N-Tert-butyl-3-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]pyridin-2-yl]piperidin-4-yl]imidazole-4-carboxamide

CAS Number: 2012607-27-9
Compound CID: 121487936

Product Size

1 mg; 5 mg; 10 mg; 20 mg

Price

Datasheet

MSDS

Properties

Description

WNK463, soluble in DMSO and ethanol and insoluble in water, is an orally bioavailable pan-WNK-kinase inhibitor. The molecular weight of the compound is 463.46, and its molecular formula is C₂₁H₂₄F₃N₇O₂.

Molecular Weight

463.46

Molecular Formula

C₂₁H₂₄F₃N₇O₂

Form

Lyophilized powder

Purity

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 81 mg/mL (174.77 mM); Water: insoluble; Ethanol: 81 mg/mL (174.77 mM); In vivo: 5% DMSO + 30% PEG 300 + 5% Tween 80 + ddH₂O, 7 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

WNK463 can be studied extensively for its potential therapeutic applications in the treatment of hypertension and related cardiovascular conditions by modulating renal function and sodium transport.