Mastering Sugar Heterogeneity, Accelerating Drug Discovery

Saccharides, compounds formed by covalent bonding of saccharides, biomolecules (such as proteins, peptides, lipids, nucleic acids, and antibodies), and other small molecules are ubiquitous. They are located on the cell surface and inside the cell and play a key role in cell interaction, the development of vaccines against cancer, viral and bacterial infections, and many other diseases. The conjugation of sugar and other substances also improves the original properties of these substances, such as stability and solubility.

Proteins and nucleic acids can be obtained in a homogeneous form through recombinant expression and polymerase chain reaction, respectively. Unlike them, the biosynthesis of sugars and glycoconjugates does not have a fixed template or uniform model. Therefore, sugar-related substances isolated from biological samples usually exist in the form of heterogeneous mixtures of different glycan structures. To solve this problem, CD BioGlyco has developed different strategies for obtaining homogenous sugar-related substances, including chemical, enzymatic, and chemoenzymatic methods, and can also provide different modifications according to customer needs. Our service helps study the structure and function of sugars and glycoconjugates and the development of new biological drugs for major diseases.

Key Technologies

Multi-modal chromatography; Chemical-enzymatic convergent synthesis; Site-specific fluorescent labeling; Multidimensional quality control (QC)

Synthesizing Glyco-Innovation: Your Blueprint, Our Mastery

We proudly present our Glyco™ synthesis platform, a cutting-edge solution designed to address the complexities of glycomolecule synthesis through a streamlined, technology-driven workflow. Our platform integrates advanced chemical, enzymatic, and computational strategies to deliver customized glycoconjugates with precision and scalability.

We specialize in synthesizing bespoke carbohydrate molecules with exceptional purity and defined stereochemistry, enabling breakthroughs in drug discovery, diagnostics, and biomaterial innovation. Our comprehensive services include:

• Custom Monosaccharide Synthesis

We produce rare or non-natural monosaccharides with specific configurations (e.g., deoxy, amino, fluorinated sugars) and isotopic labeling, serving as critical building blocks for probes, drug intermediates, and metabolic studies.

• Custom Disaccharide Synthesis

Precise construction of disaccharides with controlled glycosidic linkages (α/β-1,4; 1,6, etc.), leveraging enzymatic, chemoenzymatic, or catalytic C–O cross-coupling strategies for applications in glycomimetics and diagnostic research.

• Custom Oligosaccharides Synthesis

We engineer linear and branched oligosaccharides (3–10 sugar units) with precisely controlled regio- and stereochemistry, including fluorescent labeling (e.g., FITC, Cy5) for cellular tracking applications.

• Custom Complex N-linked Oligosaccharides Synthesis

High-fidelity synthesis of mammalian-type structures (e.g., high-mannose, sialylated, hybrid glycans) is essential for antibody glycosylation studies and glycoprotein engineering.

• Custom Polysaccharide Synthesis

Based on our expertise, we engineer custom polysaccharides—including hyaluronic acid, chitosan, and glycosaminoglycan (GAG) analogs—with precise molecular weights and tailored functionalization (e.g., site-specific sulfation for GAG mimetics, thiolation for crosslinkable hydrogels) using both chemical synthesis (e.g., regiospecific modification of cellulose acetate) and biotechnological approaches (e.g., enzymatic pathways, engineered microbial hosts).

• Custom Carbohydrate Antigen Synthesis

Design and production of pathogen-mimetic glycan epitopes (e.g., Lewis antigens, fucosylated glycotopes) for vaccine development and immunodiagnostic research.

Based on our integrated expertise, we custom glycolipids—including glycosphingolipids and glycoglycerolipids—through chemical synthesis, enzymatic methods, and engineered microbial platforms (e.g., E. coli expressing glycosyltransferases like MG517). We tailor sugar headgroups (glucose, galactose, sulfated GAG mimetics) and lipid tails (sphingosines, diacylglycerols) for applications in targeted drug delivery, diagnostic probes, and biomimetic membranes, with rigorous ultra-performance liquid chromatography-mass spectrometry (UPLC-MS)/NMR validation ensuring structural fidelity.

We produce high-quality glycoamino acid building blocks in-house, which allows us to efficiently synthesize a diverse range of glycopeptides, including N- and O-linked glycopeptides, lipopeptides, glycolipopeptides, and macrocyclic peptides, as well as those labeled with fluorescent, biotin, or stable isotope markers. Our capabilities extend to tackling challenging syntheses, such as highly branched, multi-functional, non-canonical, and post-translationally modified glycopeptides, all tailored for specific biological applications.

We generate structurally defined glycoproteins by unifying chemical synthesis, enzymatic pathways, and innovative coupling methods (e.g., thioacid chemistry) for accurate glycan positioning. This enables us to deliver homogeneous glycoproteins—tailored for specific sugar composition, linkage, and site occupancy—to study structure-function relationships and develop therapeutics with optimized properties such as enhanced stability, reduced immunogenicity, or targeted bioactivity.

We design your specific glycoconjugate by defining the target molecule (like a protein, peptide, or lipid) and the desired carbohydrate structure(s) to attach. We then synthesize it, either by chemically or enzymatically attaching the chosen sugars to specific sites on your molecule. After building the glycoconjugate, we carefully purify it to remove impurities and rigorously analyze it (using techniques like MS and HPLC) to confirm its identity, purity, and correct structure.

We engineer structurally defined glycosides by combining chemical and enzymatic approaches to deliver tailored saccharide constructs—from monosaccharides to complex oligosaccharides—across milligram to kilogram scales. Our integrated platform ensures rigorous quality validation through advanced analytical techniques (e.g., high-field NMR, MS), supported by a team of specialists dedicated to providing bespoke solutions for your R&D and production challenges.

We construct your specific activated glycosyl donor by designing its exact sugar structure (like glucose, galactose, or a more complex oligosaccharide) and choosing the optimal activating group (such as a trichloroacetimidate, thioglycoside, or glycosyl halide) for your intended reaction. We then chemically build it, carefully installing protecting groups to control reactivity and precisely attaching the activating group at the sugar's anomeric position. After synthesis, we purify the donor to high standards and rigorously analyze it to confirm its identity, purity, and stability, delivering it ready for your glycosylation reactions.

We deliver precision-engineered thioglycosides by first designing your target saccharide architecture—from monosaccharides to complex oligosaccharides—and pairing it with tailored thiol aglycones. Our synthesis hinges on chemoselective C–S bond formation at the anomeric center, leveraging stereocontrolled methodologies to ensure α/β selectivity and strategic protecting group orchestration. Post-synthesis, we rigorously purify constructs via chromatography and validate structural integrity through advanced NMR spectroscopy and MS, guaranteeing high purity for immediate deployment as glycosyl donors or hydrolytically stable intermediates.

We engineer phosphatidylinositol to exact specifications by tailoring fatty acid chains on the glycerol backbone and phosphorylation states on the inositol ring. Through stereocontrolled chemical synthesis or chemoenzymatic assembly, we construct the lipid architecture, ensuring regiospecific attachment of the inositol headgroup to the phosphatidic acid core and precise phosphate installation at designated inositol positions. Post-synthesis deprotection is followed by rigorous purification (HPLC) and multidimensional validation to confirm structural fidelity.

We offer custom cyclodextrin synthesis where we expertly modify native cyclodextrins (α, β, γ) to create derivatives tailored precisely to your requirements; we handle complex functionalization, purification, and characterization, providing compounds from milligram to kilogram scale for your specific research or application needs, partnering with you to solve solubility, stability, or delivery challenges.

We offer bespoke rhamnolipid synthesis, deploying microbial strain engineering coupled with fermentation protocol optimization to specifically sculpt structural attributes (mono/di-rhamnolipidic ratios), hydrophobicity determinants (chain extent, unsaturation indices), and functional efficacy tailored for distinct exigencies—exploiting Pseudomonas aeruginosa archetypes or mutagenized variants, inclusive of anaerobic catabolic routes.

We specialize in custom sphingolipid synthesis, where we precisely tailor their structural features, including long-chain bases, N-acyl chain lengths, saturation levels, and head groups. We achieve this by leveraging advanced metabolic engineering and synthetic biology strategies. Our goal is to create sphingolipids optimized for specific research or therapeutic applications. To ensure the purity, accurate quantification, and functional validation of these tailored molecules, we employ high-throughput mass spectrometric techniques and advanced lipidomics technology.

We deliver precision-engineered custom building blocks for glycobiology research. Using advanced chemical synthesis and enzymatic processes, we provide tailored intermediates (heterocyclic, fluorinated, nitrogenous, aromatic, etc.) to accelerate your drug discovery and compound development.

Our biocatalytic methods ensure high-purity, eco-friendly synthesis under mild conditions, reducing costs and environmental impact. Every building block undergoes rigorous quality verification via liquid chromatography (LC)-MS, NMR, and gas chromatography (GC)-MS to guarantee reliability for:

• Combinatorial carbohydrate libraries
• Glycopeptide engineering
• Bioactive compound synthesis

We specialize in providing comprehensive carbohydrate manufacturing services, focusing on large-scale synthesis to support research in materials science, biomedicine, high-affinity ligand development, and drug delivery systems. Our offerings include the production of carbohydrate-based active pharmaceutical ingredients (APIs), glycosylation site-specific antibody-drug conjugate (ADC) development platforms, and enzymatic modification-based ADC development, all designed to accelerate your projects. Leveraging our extensive experience in glycobiology, we ensure a secure supply of high-quality carbohydrate products, constantly update our methods with cutting-edge scientific advances, and provide real-time expert guidance throughout your project lifecycle.

We excel at developing and refining synthesis processes for challenging carbohydrate-based molecules. Employ advanced chemical, enzymatic, and chemo-enzymatic methodologies to achieve high efficiency and stereoselectivity. Rigorous purity analysis and stability testing are integrated early to guarantee exceptional product quality. This commitment to process excellence allows us to deliver cost-effective, custom synthesis of diverse targets, empowering your research in biopharmaceuticals, cell biology, and target identification.

• Nucleoside&Nucleotide Synthesis Service
  At CD BioGlyco, we specialize in providing high-quality nucleoside & nucleotide synthesis services. We understand the critical biological roles of these molecules as the building blocks of nucleic acids and their importance in cellular processes and therapeutics. Our custom sugar-nucleotides are vital tools for studying glycoconjugate biosynthesis, developing enzyme inhibitors, and researching carbohydrate structure/function. Key advantages include our ability to synthesize diverse nucleotide sugars, outstanding process development and optimization, customized route design, and expertise in selecting appropriate counterions for purity. We offer diverse synthesis approaches tailored to client needs, including:

  Nucleoside Chemical Synthesis Service	Nucleoside Enzymatic Synthesis Service	Nucleoside Cell Factory Synthesis Service
  Nucleotide Chemical Synthesis Service	Nucleotide Microbial Synthesis Service	Nucleotide Enzymatic Digestion Service

• Custom Oligonucleotide Synthesis Service
  We provide comprehensive custom oligonucleotide synthesis services to support diverse research needs. Our key offerings include:
  • Chemical-based Oligonucleotide Synthesis Service:
    We possess excellent chemical synthesis capabilities, utilizing advanced technology and optimized reaction processes to produce high-quality oligonucleotides. We synthesize both unmodified, standard products and complex modified oligonucleotides, constantly refining our methods to ensure optimal product quality.
    Solid-phase Chemical Synthesis Method

    

    Liquid-phase Chemical Synthesis Method

    
    • Enzymatic Synthesis Method for Oligonucleotide
      We also leverage biological enzyme-based synthesis technologies, recognizing their significant potential. Our enzymatic methods allow us to efficiently join small fragments into larger ones, accelerating the synthesis process. We continuously optimize this enzymatic synthesis process to meet evolving research demands.
    • Oligonucleotide Fragment Purification Service
      To ensure purity and isolate target products from synthesis side reactions, we offer optimized purification services. We provide various methods, including oligonucleotide purification cartridge (OPC) column purification, HPLC purification, direct desalting purification, and polyacrylamide gel purification (PAGE) purification. We select and perform the appropriate purification method based on specific client requirements.
      Desalination-based Oligonucleotide Fragment Purification Service

      

      OPC-based Oligonucleotide Fragment Purification Service

      

      HPLC-based Oligonucleotide Fragment Purification Service

      

      PAGE-based Oligonucleotide Fragment Purification Service

      
• Polynucleotide Synthesis Service
  • Custom Deoxyribonucleic Acid (DNA) Synthesis Service
    Leveraging both Chemical Synthesis (solid-phase phosphoramidite chemistry) and Enzymatic Synthesis (utilizing terminal deoxynucleotidyl transferase/TdT), we produce high-quality DNA sequences. Our enzymatic method excels at synthesizing longer strands with minimal side products. We further specialize in creating innovative DNA hybrids integrated with inorganic nanomaterials like gold, magnetic particles, and silver for cutting-edge bio-applications. Our synthetic DNA serves as a powerful research tool across life sciences, materials science, and nanotechnology, offering benefits like sequence independence, automation readiness, and sustainable production.
  • Custom Ribonucleic Acid (RNA) Synthesis Service
    We offer custom RNA synthesis solutions for a wide range of research applications. Our approach includes automated solid-phase chemical synthesis using specialized protecting groups (TOM/TBDMS for 2' OH, DMT for 5' OH) and high-yield enzymatic transcription with T7 RNA polymerase. Our streamlined four-step process—deacetylation, coupling, capping, and oxidation—ensures precise chain elongation from 3' to 5'. Additionally, we provide custom modifications to meet specific project needs.
  • DNA and RNA Purification Service
    We provide high-purity DNA and RNA purification services for research and therapeutics. Our methods include PAGE-based separation to isolate full-length nucleotides and advanced HPLC techniques—reversed-phase, ion-exchange, and ion-paired chromatography—to remove by-products, enzymes, and contaminants. We can handle various modifications like fluorescein and phosphorothioate, ensuring high recovery and compatibility with MS.
    PAGE-based DNA and RNA Purification Service

    

    HPLC-based DNA and RNA Purification Service

    
• Nucleoside&Nucleotide Modification Service
  Providing comprehensive nucleoside and nucleotide modification services to advance cutting-edge research and drug development. Utilizing the advanced Glyco™ synthesis platform to deliver customized modifications, including base alterations, sugar methylation and phosphorylation, phosphate group changes, and labeling with fluorescence, isotopes, or radionuclides.
  • Base-based Modification Service
    We focus on modifying nucleosides and nucleotides using advanced organic synthesis techniques. Our expertise includes halogenation, N-conjugation, and azotation, which improve properties like solubility, stability, and bioaffinity.

    Base-based Halogenation Modification Service	Base-based N-conjugation Modification Service	Base-based Azotation Modification Service

  • Sugar-based Modification Service
    Leveraging our specialized Glyco™ synthesis platform, we deliver comprehensive sugar moiety modification services phosphorylation, halogenation, ring saturation, hydroxylation/dehydroxylation, and glycosidic bond engineering. These precise modifications enhance nucleic acid stability, binding affinity, and biological functionality to support critical applications.

    Sugar-based Halogenation Modification Service	Sugar-based Methylation Modification Service	Sugar-based Ring Modification Service	Sugar-based Saturation Modification Service
    Sugar-based Hydroxylation or Dehydroxylation Modification Service	Glycosidic Bond Modification Service	Nucleotide Stereo- and Enantio-selective Reaction Modification Service

  • Phosphate Group-based Modification Service
    Leveraging our Glyco™ synthesis platform, we engineer targeted phosphate group modifications—including P-O to P-N bond conversion, mono-/di-/tri-phosphate adjustments, and phosphoramide integration—to transform nucleotide functionality.

    Phosphate Group Production by Polar Group Service	Phosphate Group Replacement of P-O Bond by P-N Bond Service	Mono-, Di-, and Tri-phosphate Modification Service	Phosphoramide-based Nucleotide Modification Service

  • Fluorescent Labeling Modification Service
    Deploying advanced covalent conjugation techniques, we engineer site-specific fluorescent labeling of nucleosides and nucleotides through:
    • Direct labeling: Covalent attachment of fluorophores (e.g., fluoresceins, rhodamines) to pentose backbones or via triphosphate incorporation, followed by HPLC purification to eliminate truncations
    • Indirect labeling: Bioconjugation through stable linker systems that preserve bioactivity while enabling ligand-specific detection
  • Stable Isotope Labeling Modification Service
    Harnessing our platform, we engineer stable isotope-labeled nucleosides/nucleotides (²H, ¹³C, ¹⁵N, ¹⁸O, ¹⁹F) through advanced chemical and enzymatic methods to enable:
    • Metabolic pathway mapping via isotope tracing
    • Quantitative MS analysis using >98% enriched internal standards
    • High-resolution NMR structural studies
    • Short for nucleic acid isotope labeling coupled mass spectrometry (NAIL-MS) dynamic modification profiling
  • Radionuclide Labeling Modification Service
    We specialize in precision radiolabeling of nucleosides and nucleotides using our Glyco™ synthesis platform. Building on many years of radiochemistry expertise, we engineer site-specific incorporation of isotopes (³H, ¹⁴C, ³²P, ³³P, ³⁵S) into:
    • Ribo/deoxyribonucleosides (rNs/dNs)
    • Mono/di/tri-phosphates (NMPs/NDPs/NTPs)
    • Specialized building blocks
• Oligonucleotide Modification Service
  • Oligonucleotide-based Phosphorylation Modification Service
    We specialize in custom 5' and 3' phosphorylation modifications for DNA/RNA oligonucleotides using advanced chemical strategies. Our services enhance functionality for critical applications:
    • PCR optimization: Stabilized primers improve binding specificity and amplification efficiency
    • Enzyme substrates: Modified oligonucleotides serve as essential substrates for DNA/RNA polymerases
    • Aptamer engineering: Increased stability and binding affinity for diagnostic/therapeutic development
    • Synthetic biology: Enables recombinant DNA construction and gene editing workflows
  • Oligonucleotide-based Phosphorothioate Backbone Modification Service
    We provide precision phosphorothioate backbone modifications, strategically replacing oxygen with sulfur in oligonucleotides to confer exceptional nuclease resistance and enhanced cellular uptake. Our methodology enables site-specific sulfur substitutions (5'/3'/full backbone) with controlled Rp/Sp isomer ratios, rigorously purified via HPLC/PAGE and validated by MS. These stability-enhanced constructs power therapeutic siRNA delivery systems, diagnostic probes, and platelet signaling studies.
  • Oligonucleotide-based Sugar Ring Modification Service
    Oligonucleotide duplex stability and protein binding dynamics are determined by targeted modifications of the furanose sugar ring. At CD BioGlyco, strategic alterations are introduced at the 2', 4', or 5' positions—including 2'-methoxy (2'-OMe), 2'-O-methoxyethyl, and 2'-amino groups—to direct sugar puckering toward 3'-endo conformation.
  • Oligonucleotide-based Base Modification Service
    CD BioGlyco's oligonucleotide-based base modification provides chemical modifications to oligonucleotide bases, such as affinity-plus bases, 2'-O-methoxy-ethyl (2'-MOE), 2'-O-methyl RNA bases, inosine, and fluoro bases, to enhance stability, binding affinity, and nuclease resistance for therapeutic applications. These modifications address the rapid degradation of unmodified RNA by nucleases and optimize nucleic acid drugs for use in molecular diagnostics, biomedical research, and drug development.
    Oligonucleotide-based Affinity-plus Base Modification Service

    

    Oligonucleotide-based Inosine Modification Service

    

    Oligonucleotide-based 2'-MOE Modification Service

    
    Oligonucleotide-based 2'-O-Methyl RNA Bases Modification Service

    

    Oligonucleotide-based Fluoro Bases Modification Service

    
  • Oligonucleotide-based Linker Modification Service
    We modify oligonucleotides with specialized linkers (amino, biotin, thiol, etc.) using bio-orthogonal chemistry and precision synthesis. These modifications confer critical advantages: increased stability against nucleases, enhanced cellular uptake, and optimized drug-like properties for therapeutic nucleic acids.
    Amino-based Oligonucleotide Modification Service

    

    Biotin-based Oligonucleotide Modification Service

    

    Thiol-based Oligonucleotide Modification Service

    

    Alkyne-based Oligonucleotide Modification Service

    

    Azide-based Oligonucleotide Modification Service

    

    Adenylation-based Oligonucleotide Modification Service

    

    Digoxigenin-based Oligonucleotide Modification Service

    
  • Oligonucleotide Fluorophore Modification Service
    Harnessing covalent chemistry, specialized oligonucleotide probes emerge with site-specific fluorophores (FAM, HEX, Cy3/5, TAMRA, BHQ, etc.) precisely anchored at 5'/3' ends, nucleobases, or ribose structures. These engineered tools—purified via HPLC or ion-exchange chromatography—become molecular flashlights for real-time polymerase chain reaction (PCR), gene chips, and multiplex assays, illuminating targets in clinical diagnostics, environmental monitoring, and forensic analysis.

    Oligonucleotide Fluorescein Labeling Service	Oligonucleotide Carboxyfluorescein (FAM) Labeling Service	Oligonucleotide Tetrachlorofluorescein (TET) Labeling Service	Oligonucleotide Hexachlorofluorescein (HEX) Labeling Service
    Oligonucleotide Cy3 & Cy5 Labeling Service	Oligonucleotide TAMRA Labeling Service	Oligonucleotide Dabcyl Labeling Service	Oligonucleotide BHQ Labeling Service

  • Nucleoside-based Production Service
    CD BioGlyco produces custom nucleosides, including natural types, synthetic derivatives, nitrogenous bases, and modified variants for genetic research. Their products support anti-tumor drug discovery, pharmaceutical intermediates, and food additive R&D. Leveraging analytical expertise, they deliver tailored solutions for nucleotide studies.

    Nucleoside-based Nitrogenous Base Production Service	Nucleoside-based Ribonucleoside Production Service	Nucleoside-based Deoxyribonucleoside Production Service
    Adenine Production Cytosine Production Guanine Production Uracil Production Thymine Production	Adenosine Production Cytidine Production Guanosine Production Uridine Production 5-Methyluridine Production	Deoxyadenosine Production Deoxyguanosine Production Thymidine Production Service Deoxyuridine Production Service Deoxycytidine Production Service
    Nucleoside-based Derivative Production Service
    Deoxyadenosine Derivative Production Deoxycytidine Derivative Production Deoxyguanosine Derivative Production Deoxythymidine Derivative Production Deoxyuridine Derivative Production Dideoxynucleotide Derivative Production	Adenosine Derivative Production Adenine Derivative Production Cytosine Derivative Production Cytidine Derivative Production Guanosine Derivative Production Guanine Derivative Production	Uridine Derivative Production Uracil Derivative Production Thymine Derivative Production Ribothymidine Derivative Production Different Backbone Sugar-based Derivative Production

  • Nucleotide-based Production Service
    Our researchers offer high-purity nucleotide production services (including NMP, NDP, NTP, and custom derivatives) for research purposes, utilizing both chemical and biosynthetic strategies. We highlight nucleotides' essential biological roles as precursors for DNA/RNA, energy carriers (like ATP), and participants in metabolism, as well as the therapeutic potential of derivatives in areas like cancer and antiviral research.

    Nucleotide Monophosphate Production Service
    	Adenine Nucleotide Guanine Nucleotide Cytosine Nucleotide Thymine Nucleotide Uracil Nucleotide cAMP	cGMP FAD FMN NAD NADP pppGpp
    NDP Production Service	NTP Production Service	Nucleotide Derivative Production Service
    ADP CDP GDP UDP	ATP CTP GTP UTP Acetoacetyl Coenzyme A Acetyl Coenzyme A	Adenine Nucleotide Derivative Cytosine Nucleotide Derivative Guanine Nucleotide Derivative Uracil Nucleotide Derivative Thymine Nucleotide Derivative

  • One-pot Multienzyme (OPME)-based NDP-sugar Synthesis Service
    CD BioGlyco delivers an integrated OPME platform for synthesizing nucleotide diphosphate sugars (NDP-sugars), utilizing a unified enzymatic cascade to convert monosaccharides and acceptor molecules into complex NDP-sugar products. This methodology eliminates multi-step purification through synchronized reactions—including substrate activation, glycosyl transfer, cofactor regeneration, and product formation—within a single reactor, thereby maximizing yield efficiency and ensuring reaction purity. The service enables scalable production of diverse NDP-sugars (e.g., UDP-glucose, GDP-mannose) to advance research in glycoconjugate biosynthesis, polysaccharide engineering, and therapeutic development targeting glycosylation-related enzymes.
  • OPME-based NMP-sugar Synthesis Service
    We utilize efficient OPME technology to synthesize nucleotide monophosphate sugars (e.g., CMP-sialic acid). By integrating multiple enzymes into a single reaction vessel, this platform directly converts precursor substrates into target NMP-sugars without intermediate purification. The optimized enzymatic cascade ensures critical high stereo-/regio-selectivity for accurate glycan assembly.

Workflow

Publication Data

Associated Services

Applications

• Glyco™ synthesis platform can be used to synthesize structurally defined glycan probes (e.g., sialylated oligosaccharides, blood group antigens) to map lectin binding specificities, unraveling mechanisms of cell adhesion, pathogen invasion, and immune recognition.
• Glyco™ synthesis platform can be applied to generate pathological glycoforms (e.g., hypersialylated tumor antigens, truncated O-glycans in cancer) to study how aberrant glycosylation drives metastasis, immune evasion, and therapeutic resistance.
• Glyco™ synthesis platform enables kinetic profiling of glycosyltransferases/glycosidases, accelerating inhibitor discovery for glycosylation-related disorders.

Advantages

• We implement multidimensional validation through advanced analytical techniques—including HPLC-CAD, SEC-MALS, NMR, and LC-MS—to ensure >95% purity and structural fidelity.
• Stability testing is integrated within the process development phase to guarantee reliable product performance.
• Our capabilities include kilogram-scale manufacturing of carbohydrate APIs, cyclodextrins, and glycoconjugates via optimized microbial fermentation or chemical synthesis.

Frequently Asked Questions

CD BioGlyco has many years of experience in the field of custom synthesis. We have a professional technical team to provide guidance for customers' projects and tailor synthesis schemes according to needs. We hope to start the exploration of glycobiology with you. If you are interested in our services, please contact us for more detailed information.