CD BioGlyco

Can RNA also "Decorate" the Cell Surface? In the cognition of traditional biology, RNA is an "information molecule" that mainly exists in the cell nucleus and cytoplasm, and undertakes gene expression regulation, catalytic function or as a carrier of genetic information. The cell surface is generally considered to be the world of membrane proteins and […]

Glucose is the transport form of carbohydrate in the blood and occupies a major position in the body's carbohydrate metabolism. The metabolic pathways of carbohydrate in the body mainly include Glycolysis, pentose phosphate pathway, uronic acid pathway, polyol pathway, glycogen synthesis and glycogenolysis, gluconeogenesis, and other hexose metabolism. Here are a few recent studies summarized […]

Research Background Affinity labeling proteins are important detection and analysis tools in the field of life sciences. For example, high-affinity monoclonal antibodies against proteins can achieve accurate and sensitive detection of proteins in different experimental scenarios. Glycans, as an important class of biomacromolecules, carry a wealth of life information. Effective affinity labeling of glycans is an […]

Introduction The team of Cristina De Castro from the University of Napoli and Fabrizio Chiodo from the Vrije University Amsterdam published an article titled "Carbohydrate-mediated interactions between chloroviruses and the immune system" in Communications Biology. The article studied the Carbohydrate-mediated interactions between chloroviruses and the Immune System from different angles. Studies have shown that some large viruses are […]

Application of cryo-EM Technology and AI in Structural Biology Cryo-electron microscopy (cryo-EM) technology has brought about a resolution revolution, allowing us to observe and depict protein structures at atomic-level high resolution. Artificial intelligence (AI)-based tools such as AlphaFold have achieved rapid and accurate prediction of protein structures. Today, AlphaFold has predicted the structures of almost […]

Metabolic reprogramming has been a hot topic in recent years, including glycolysis and lactic acid modification in recent years. Nowadays, "mannose" has also come into everyone's sight, leading to a new research angle. On January 13, 2025, the team of Guideng Li of the Chinese Academy of Medical Sciences & Peking Union Medical College published […]

Introduction to Glycosylation Modification Glycosylation modification is a common post-translational modification process in cells, involving the covalent attachment of one or more sugar groups to proteins or other organic molecules. This modification affects protein folding, stability, activity, and intercellular signaling. There are two main types of glycosylation modification: N-glycosylation and O-glycosylation. For example, many cell […]

When the resolution is raised from 3 Å to 2.3 Å, a magical world emerges: an unprecedented 5',5'-phosphodiester bond is directly observed, weaving adjacent sugar chains into a sugar network! You don't know until you "see", the world is really amazing! However, what has been reported so far is only a superficial observation, and a […]