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Akt inhibitor A-674563, Purity ≥98%
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Cat. No.: X23-10-ZQ812

Akt inhibitor A-674563, Purity ≥98%

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Synonym: A-674563; 552325-73-2; A674563; A 674563; (2S)-1-{[5-(3-Methyl-1H-Indazol-5-Yl)pyridin-3-Yl]oxy}-3-Phenylpropan-2-Amine; 3W2X0WGW6C; (S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine; Akt inhibitor

  • MDL: MFCD11840461
  • CAS Number: 552325-73-2
  • Compound CID: 11314340
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
A-674563, soluble in DMSO, water and ethanol, is a potent compound that inhibits Akt kinase activity. It targets CDK2, PKA, Akt1, c-Kit, Chk1, CK2, ERK2, FLT1, GSK-3β, KDR, and MAPK-AP2.
Molecular Weight
358.4
Molecular Formula
C22H22N4O
Targets
CDK2: 46 nM (Ki); PKA: 16 nM (Ki); Akt1: 11 nM (Ki); c-Kit: >5.8 μM (Ki); Chk1: 2.6 μM (Ki); CK2: 5.4 μM (Ki); ERK2: 260 nM (Ki); FLT1: >2.2 μM (Ki); GSK-3β: 110 nM (Ki); KDR: >3.7 μM (Ki); MAPK-AP2: 1.1 μM (Ki)
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 71 mg/mL (198.08 mM); Water: 71 mg/mL (198.08 mM); Ethanol: 18 mg/mL (50.21 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
A-674563 can be used to examine its inhibition of Akt kinase and its effects on cell survival and proliferation.
Publications
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