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Akt inhibitor Afuresertib, Purity ≥98%
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Cat. No.: X24-05-ZQ182

Akt inhibitor Afuresertib, Purity ≥98%

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Synonym: 1047644-62-1; GSK 2110183; GSK2110183; GSK-2110183; Akt inhibitor

  • CAS Number: 1047644-62-1
  • Compound CID: 46843057
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Product Size
5 mg; 10 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Afuresertib, soluble in DMSO and ethanol and insoluble in water, inhibits the phosphorylation of Akt with anti-inflammatory properties. It targets Akt1 E17K mutant, Akt2, Akt3, PKCη, PKCθ, PKC-βI, and ROCK.
Molecular Weight
427.32
Molecular Formula
C18H17Cl2FN4OS
Targets
Akt1 E17K mutant: 0.2 nM; Akt2: 2 nM (Ki); Akt3: 2.6 nM (Ki); PKCη: 210 nM (Ki); PKCθ: 510 nM; PKC-βI: 430 nM; ROCK: 100 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 79 mg/mL (184.87 mM); Water: Insoluble; Ethanol: 79 mg/mL (184.87 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
Afuresertib can be used to study its inhibitory effect on Akt in cancer research.
Publications
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