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ALK inhibitor PF-06463922, Purity ≥98%
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Cat. No.: X24-06-ZQ314

ALK inhibitor PF-06463922, Purity ≥98%

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Synonym: 1454846-35-5; ALK inhibitor; PF 06463922; PF06463922

  • MDL: MFCD28144520
  • CAS Number: 1454846-35-5
  • Compound CID: 71731823
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Product Size
5 mg; 10 mg; 25 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
PF-06463922, soluble in warmed DMSO and warmed ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against ALK. It targets ALK, ROS1, ALK (L1196M), DCAMKL2(DCK2), EGFR(ErbB1)T790M, EGFR(ErbB1)T790ML858R, EPHA1, FER, FES(FPS), FRK(PTK5), and IGF1R.
Molecular Weight
406.41
Molecular Formula
C21H19FN6O2
Targets
ALK: <0.07 nM (Ki); ROS1: <0.02 nM (Ki); ALK (L1196M): 0.07 nM (Ki); DCAMKL2 (DCK2): 370 nM; EGFR (ErbB1) T790M: 319 nM; EGFR (ErbB1) T790ML858R: 245 nM; EPHA1: 375 nM; FER: 3.3 nM; FES (FPS): 6 nM; FRK (PTK5): 53 nM; IGF1R: 296 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
Warmed DMSO: 70 mg/mL (172.23 mM); Water: Insoluble; Warmed ethanol: 26 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
PF-06463922, also known as lorlatinib, is studied for its effectiveness in overcoming resistance in ALK-positive cancers.
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