PUBLIC DISCLOSURE & CLARIFICATION

BioGlyco supplement products (including BioGlyco Flow, BioGlyco Capsules, and BioGlyco Blood) are not affiliated with CD BioGlyco.

CD BioGlyco does not manufacture, distribute, or provide after-sales support for these consumer products. For any product-related questions, please contact the original seller directly.

ALK inhibitor PF-06463922, Purity ≥98%

Inquiry

Cat. No.: X24-06-ZQ314

ALK inhibitor PF-06463922, Purity ≥98%

Synonym: 1454846-35-5; ALK inhibitor; PF 06463922; PF06463922

MDL: MFCD28144520
CAS Number: 1454846-35-5
Compound CID: 71731823

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

MSDS

Properties

Description

PF-06463922, soluble in warmed DMSO and warmed ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against ALK. It targets ALK, ROS1, ALK (L1196M), DCAMKL2(DCK2), EGFR(ErbB1)T790M, EGFR(ErbB1)T790ML858R, EPHA1, FER, FES(FPS), FRK(PTK5), and IGF1R.

Molecular Weight

406.41

Molecular Formula

C₂₁H₁₉FN₆O₂

Targets

ALK: <0.07 nM (Ki); ROS1: <0.02 nM (Ki); ALK (L1196M): 0.07 nM (Ki); DCAMKL2 (DCK2): 370 nM; EGFR (ErbB1) T790M: 319 nM; EGFR (ErbB1) T790ML858R: 245 nM; EPHA1: 375 nM; FER: 3.3 nM; FES (FPS): 6 nM; FRK (PTK5): 53 nM; IGF1R: 296 nM

Form

Lyophilized powder

Purity

Solubility

Warmed DMSO: 70 mg/mL (172.23 mM); Water: Insoluble; Warmed ethanol: 26 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

PF-06463922, also known as lorlatinib, is studied for its effectiveness in overcoming resistance in ALK-positive cancers.

Publications

Publications (0)

Publications

Publications

Thank you for choosing our products for your research. By sharing your publications or experimental feedback, you provide invaluable insights that help fellow scientists accelerate their discoveries. Your contribution also drives our commitment to continuous product optimization.

As a token of our appreciation, verified submissions will receive an exclusive discount code for your next order.

*Submitted research data and images may be featured on our product pages. We strictly protect your personal privacy; no sensitive contact information will ever be disclosed.