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Antisense oligonucleotide pH-sensitive proliposomes

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Cat. No.: X26-05-ZQ1461

Antisense oligonucleotide pH-sensitive proliposomes

Name: Antisense oligonucleotide pH-sensitive proliposomes
SKU: X26-05-ZQ1461

Inquiry

Synonym: Antisense oligonucleotide pH-sensitive PLs; AON acid-sensitive proliposomes; Antisense oligonucleotide pH-responsive proliposomes

Product Size

100 mg; 250 mg; 500 mg; 1 g; 5 g

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

This highly responsive formulation features antisense oligonucleotide pH-sensitive proliposomes designed as a dry-state precursor for a stimulus-responsive nucleic acid complexation model. The solid microarchitecture consists of a water-soluble carbohydrate carrier network uniformly coated with dehydrated antisense oligonucleotides (ASODNs) alongside pH-sensitive lipids (such as dioleoylphosphatidylethanolamine and cholesteryl hemisuccinate). This dry configuration completely prevents the rapid chemical hydrolysis of the phosphodiester bonds and eliminates premature vesicle aggregation during extended storage. Upon standard hydration with an aqueous buffer, the matrix self-assembles into a uniform suspension of pH-sensitive liposomes that undergo phase changes under acidic conditions.

Source

Custom synthesis

Functional Group

Antisense oligonucleotide

Form

Solid or powder

Purity

≥95%

Impurities

No visible impurities to the naked eye.

Identity

HPLC/MS/NMR

Publications

Publications (0)

Publications

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Publications

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