Artesunate is a water-soluble, semi-synthetic derivative of the sesquiterpene lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities. Upon hydrolysis of artesunate's active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells, reactive oxygen species and carbon-centered radicals form, which have been shown to damage and kill parasitic organisms. Additionally, in vitro studies demonstrate that this agent induces DNA breakage in a dose-dependent manner. Artesunate has also been shown to stimulate cell differentiation, arrest the cell cycle in the G1 and G2/M phases, inhibit cell proliferation, and induce apoptosis through mitochondrial and caspase signaling pathways. This product can be used for research in the fields of health products and pharmaceuticals.
Molecular Weight
384.425
Molecular Formula
C19H28O8
Form
Powder
Purity
≥98%, determined by HPLC.
Identity
Confirmed by MS and NMR.
Applications
Artesunate can be used for research in the fields of health products and pharmaceuticals.
Safety Information
Personal Protective Equipment
Gloves, eyeshields, N95 mask
Publications
Publications (0)
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Publications
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