Cat. No.: X24-06-ZQ224
c-MET inhibitor SU11274, Purity ≥98%
Synonym: 658084-23-2; c-MET inhibitor; SU-11274; PKI-SU11274
- MDL: MFCD08276928
- CAS Number: 658084-23-2
- Compound CID: 9549297
Product Size
5 mg; 10 mg; 50 mg; 100 mg
Properties
Description
SU11274, soluble in DMSO and ethanol and insoluble in water, inhibits the enzymatic activity of the c-Met tyrosine kinase, the receptor of hepatocyte growth factor/scatter factor (HGF/SF), interfering with pathways leading to cell growth and metastasis. It targets Flk1, RON, CDK2, EGFR, FGFR1, MET, and PDGFRβ.
Molecular Formula
C28H30CIN5O4S
Targets
Flk-1: 1.25 μM; RON: 4.0 μM; CDK2: >10 μM; EGFR: >100 μM; FGFR1: 8.5 μM; MET: 0.01 μM; PDGFRβ: >20 μM
Solubility
DMSO: 83 mg/mL (146.1 mM); Water: Insoluble; Ethanol: 2 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
SU11274 is a c-MET inhibitor, providing research insights into the modulation of oncogenic signaling cascades.
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