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c-Ret inhibitor Amuvatinib hydrochloride, Purity ≥98%
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Cat. No.: X24-06-ZQ175

c-Ret inhibitor Amuvatinib hydrochloride, Purity ≥98%

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Synonym: 1055986-67-8; c-Ret inhibitor; MP470 hydrochloride; MP 470; MP-470; HPK 56 hydrochloride; HPK56; HPK-56

  • CAS Number: 1055986-67-8
  • Compound CID: 16058702
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Product Size
5 mg; 10 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Amuvatinib hydrochloride primarily acts by blocking the ATP-binding site of the kinase domain of the RET protein, thereby inhibiting its autophosphorylation. It targets c-Kit (D816H), c-Kit (D816V), c-Kit (V560G), c-Kit (V654A), PDGFRα (D842V), and PDGFRα (V561D).
Molecular Weight
483.97
Molecular Formula
C23H21N5O3S.xHCl
Targets
c-Kit (D816H): 10 nM; c-Kit (D816V): 950 nM; c-Kit (V560G): 34 nM; c-Kit (V654A): 127 nM; PDGFRα (D842V): 81 nM; PDGFRα (V561D): 40 nM
Form
Lyophilized powder
Purity
≥98%
Identity
Confirmed by NMR/HPLC/MS.
Applications
Amuvatinib hydrochloride serves as a c-Ret inhibitor used in researching targeted cancer therapies, particularly for tumors with c-Ret mutations.
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