Properties
Description
GV-58 blocks the entry of calcium into cells, particularly in the heart and blood vessels. It targets N-type calcium channel and P/Q-type calcium channel.
Molecular Formula
C18H26N6OS
Targets
N-type calcium channel: 7.21 μM (EC50); P/Q-type calcium channel: 8.81 μM (EC50)
Identity
Confirmed by NMR/HPLC/MS.
Applications
GV-58 is employed in research to inhibit voltage-gated calcium channels, critical for neurotransmitter release and muscle contraction.