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CDK inhibitor JNJ-7706621, Purity ≥98%
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Cat. No.: X23-10-ZQ472

CDK inhibitor JNJ-7706621, Purity ≥98%

Synonym: JNJ-7706621; 443797-96-4; JNJ7706621; 4-((5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl)amino)benzenesulfonamide; 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide; 4-({5-Amino-1-[(2,6-Difluorophenyl)carbonyl]-1H-1,2,4-Triazol-3-Yl}amino)benzenesulfonamide; CDK inhibitor

  • CAS Number: 443797-96-4
  • Compound CID: 5330790
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
MSDS
Properties
Description
JNJ-7706621, soluble in DMSO and insoluble in ethanol and water, is an CDK kinase inhibitor that disrupts cell division processes. It targets Aurora A, Aurora B, Cdk1/cyclin B, cdk2/cyclin A, CDK2/cyclinE, CDK3/cyclinE, Cdk4/cyclin D1, CDK6/cyclinD1, FGF-R1, FGF-R2, and GSK3β.
Molecular Weight
394.4
Molecular Formula
C15H12F2N6O3S
Targets
Aurora A: 11 nM; Aurora B: 15 nM; Cdk1/cyclin B: 9 nM; cdk2/cyclin A: 4 nM; CDK2/cyclinE: 3 nM; CDK3/cyclinE: 58 nM; Cdk4/cyclin D1: 253 nM; CDK6/cyclinD1: 175 nM; FGF-R1: 575 nM; FGF-R2: 226 nM; GSK3β: 254 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 67 mg/mL (169.89 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
JNJ-7706621 is useful for studying the inhibition of multiple cell cycle kinases including Aurora kinase.
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