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Chloride channel inhibitor VX-770, Purity ≥98%

Cat. No.: X24-07-ZQ308

Chloride channel inhibitor VX-770, Purity ≥98%

Synonym: 873054-44-5; Chloride channel inhibitor; Kalydeco; VX770

  • MDL: MFCD17171361
  • CAS Number: 873054-44-5
  • Compound CID: 16220172
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Product Size
5 mg; 10 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
VX-770, soluble in DMSO and insoluble in ethanol and water, blocks the activity of chloride channels, which play a vital role in maintaining cellular ion balance. It targets F508del-CFTR (Fisher rat thyroid cells) and G551D-CFTR (fisher rat thyroid cells).
Molecular Weight
392.5
Molecular Formula
C24H28N2O3
Targets
F508del-CFTR (Fisher rat thyroid cells): 25 nM (EC50); G551D-CFTR: 100 nM (EC50)
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 69 mg/mL (175.8 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
VX-770 (Ivacaftor) is used as a chloride channel inhibitor in research focusing on cystic fibrosis to enhance CFTR (cystic fibrosis transmembrane conductance regulator) function.
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Blood group A trisaccharide (Cat#: XCO0060Q) Blood group B trisaccharide (Cat#: XCO0068Q) Blood group H disaccharide (Cat#: XCO0074Q) Lewis A trisaccharide (Cat#: XCO0079Q) 3'-Sulfated lewis A (Cat#: XCO0080Q) Lewis B tetrasaccharide (Cat#: XCO0083Q) Lewis X trisaccharide (Cat#: XCO0085Q) Lewis Y tetrasaccharide (Cat#: XCO0088Q)
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Lacto-N-biose (Cat#: XCO0089Q) 2'-Fucosyllactose (Cat#: XCO0091Q) 3-Fucosyllactose (Cat#: XCO0092Q) Lactodifucotetraose (Cat#: XCO0093Q) Lacto-N-triose I (Cat#: XCO0094Q) 3'-Sialyllactose sodium salt (Cat#: XCO0096Q) 6'-Sialyllactose sodium salt (Cat#: XCO0098Q) 3'-Sialyl-3-fucosyllactose (Cat#: XCO0100Q)
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Heparin amine, MW 27 kDa (Cat#: X22-09-ZQ478) FITC-heparin, MW 27 kDa (Cat#: X22-09-ZQ480) TRITC-heparin, MW 27 kDa (Cat#: X22-09-ZQ481) Biotin-heparin-FITC, MW 18 kDa (Cat#: X22-09-ZQ482) Chondroitin sulfate (dp4) (Cat#: X22-11-ZQ598) Dermatan sulfate (dp12) (Cat#: X22-11-ZQ611) Heparin disaccharide I-A (Cat#: X22-11-ZQ662) Chondroitine sulfate (Cat#: X23-04-XQ1118)
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