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Chloride channel inhibitor VX-770, Purity ≥98%
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Cat. No.: X24-07-ZQ308

Chloride channel inhibitor VX-770, Purity ≥98%

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Synonym: 873054-44-5; Chloride channel inhibitor; Kalydeco; VX770

  • MDL: MFCD17171361
  • CAS Number: 873054-44-5
  • Compound CID: 16220172
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Product Size
5 mg; 10 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
VX-770, soluble in DMSO and insoluble in ethanol and water, blocks the activity of chloride channels, which play a vital role in maintaining cellular ion balance. It targets F508del-CFTR (Fisher rat thyroid cells) and G551D-CFTR (fisher rat thyroid cells).
Molecular Weight
392.5
Molecular Formula
C24H28N2O3
Targets
F508del-CFTR (Fisher rat thyroid cells): 25 nM (EC50); G551D-CFTR: 100 nM (EC50)
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 69 mg/mL (175.8 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
VX-770 (Ivacaftor) is used as a chloride channel inhibitor in research focusing on cystic fibrosis to enhance CFTR (cystic fibrosis transmembrane conductance regulator) function.
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