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Cytochrome P450 inhibitor, Cobicistat, Purity ≥98%
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Cat. No.: X24-08-YM387

Cytochrome P450 inhibitor, Cobicistat, Purity ≥98%

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Synonym: 1004316-88-4; GS9350; Cobicistatum; 1,3-Thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate

  • MDL: MFCD18251449
  • CAS Number: 1004316-88-4
  • Compound CID: 25151504
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Product Size
2 mg; 5 mg; 10 mg; 25 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Cobicistat, soluble in DMSO and ethanol and insoluble in water, is an effective cell metabolism inhibitor, that has the ability to prevent the pathway of metabolism by inhibiting cytochrome P450. It targets the CYP3A.
Molecular Weight
766
Molecular Formula
C40H53N7O5S2
Targets
CYP3A: 30-285 nM
Form
Lyophilized powder
Purity
≥98%
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: 85 mg/mL (109.53 mM); Water: insoluble; Ethanol: 85 mg/mL (109.53 mM); In vivo: 5% DMSO + 40% PEG 300 + ddH2O, 9 mg/mL
Applications
Cobicistat is a metabolism inhibitor that can be used for its ability to increase the plasma levels of co-administered antiretroviral drugs, improving their effectiveness and reducing the frequency of dosing.
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