TH-302, soluble in DMSO, warmed water and ethanol, is an effective cell metabolism inhibitor, that has the ability to prevent the pathway of metabolism by inhibiting cytochrome P450.
Molecular Weight
449
Molecular Formula
C9H16Br2N5O4P
Form
Lyophilized powder
Purity
≥98%
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: 80 mg/mL (178.15 mM); Water (warmed): 9 mg/mL (20.03 mM); Ethanol: 80 mg/mL (178.15 mM); In vivo: 30% propylene glycol, 5% Tween 80, 65% D5W, 28 mg/mL
Applications
TH-302 is a metabolism inhibitor that can be used for its ability to release cytotoxic agents in low-oxygen environments typical of solid tumors.
Publications
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Publications
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