LDN-57444, soluble in DMSO and insoluble in ethanol and water, targets and inhibits deubiquitinating enzymes, which play a crucial role in regulating protein degradation and maintaining cellular protein homeostasis.
LDN-57444 is a DUB inhibitor applied in studies focusing on inhibiting ubiquitin C-terminal hydrolase L1 (UCHL1) and its potential in neurodegenerative diseases.
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