DUB inhibitor P 22077, Purity ≥98%

Synonym: 1247819-59-5; DUB inhibitor; P22077

MDL: MFCD22580421
CAS Number: 1247819-59-5
Compound CID: 46931953

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

P 22077, soluble in DMSO and insoluble in ethanol and water, targets and inhibits deubiquitinating enzymes, which play a crucial role in regulating protein degradation and maintaining cellular protein homeostasis. It targets USP2core, USP47, Calpain1, CathepsinD, CT-L, DEN1, JOSD2, MMP13, PLA2, Plpro, and SENP6core.

Molecular Weight

315.32

Molecular Formula

C₁₂H₇F₂NO₃S₂

Targets

USP2core: >50 μM (EC₅₀); USP47: 8.74 μM (EC₅₀); Calpain1: >50 μM (EC₅₀); CathepsinD: >50 μM (EC₅₀); CT-L: >50 μM (EC₅₀); DEN1: >50 μM (EC₅₀); JOSD2: >50 μM (EC₅₀); MMP13: >50 μM (EC₅₀); PLA2: >50 μM (EC₅₀); Plpro: >50 μM (EC₅₀); SENP6core: >50 μM (EC₅₀)

Form

Lyophilized powder

Purity

Solubility

DMSO: 57 mg/mL (180.76 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

P 22077 is a DUB inhibitor that targets the protease USP7, crucial for research in cancer and immune response regulation.