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DUB inhibitor PR-619, Purity ≥98%
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Cat. No.: X24-06-ZQ868

DUB inhibitor PR-619, Purity ≥98%

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Synonym: 2645-32-1; DUB inhibitor; PR619; PR 619

  • MDL: MFCD00830384
  • CAS Number: 2645-32-1
  • Compound CID: 2817763
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Product Size
5 mg; 10 mg; 25 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
PR-619, soluble in DMSO and insoluble in ethanol and water, targets and inhibits deubiquitinating enzymes, which play a crucial role in regulating protein degradation and maintaining cellular protein homeostasis. It targets SENP6core, UCH-L3, Calpain1, CathepsinD, CT-L, DEN1, JOSD2, MMP13, PLA2, Plpro, and Trypsin.
Molecular Weight
223.28
Molecular Formula
C7H5N5S2
Targets
SENP6core: 2.37 μM (EC50); UCH-L3: 2.95 μM (EC50); Calpain1: >50 μM (EC50); CathepsinD: >50 μM (EC50); CT-L: >50 μM (EC50); DEN1: >50 μM (EC50); JOSD2: >50 μM (EC50); MMP13: >50 μM (EC50); PLA2: >50 μM (EC50); Plpro: >50 μM (EC50); Trypsin: >50 μM (EC50)
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 42 mg/mL (188.1 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
PR-619 is a broad-spectrum DUB inhibitor utilized for its role in exploring protein deubiquitination and its implications in cellular pathophysiology.
Publications
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