Cat. No.: X24-05-ZQ436
Epigenetic reader domain inhibitor CF53, Purity ≥98%
Synonym: 1808160-52-2; CF 53; CF-53; Epigenetic reader domain inhibitor
- CAS Number: 1808160-52-2
- Compound CID: 118340554
Product Size
5 mg; 10 mg; 50 mg; 100 mg
Properties
Description
CF53 disrupts the function of proteins that recognize and bind specific epigenetic marks, affecting the interpretation of epigenetic signals. It targets BRD2-BD1, BRD2 (BD2), BRD3 (BD1), BRD3 (BD2), BRD4 (BD1), BRD4 (BD1), BRD4 (BD1), BRD4 (BD2), BRDT (BD1), BRDT (BD2), and CECR2.
Molecular Formula
C24H25N7O2
Targets
BRD2-BD1: 1.1 nM (Kd); BRD2 (BD2): 0.6 nM (Kd); BRD3 (BD1): 0.52 nM (Kd); BRD3 (BD2): 0.49 nM (Kd); BRD4 (BD1): <1 nM (Ki); BRD4 (BD1): 2 nM; BRD4 (BD1): 2.2 nM (Kd); BRD4 (BD2): 0.8 nM (Kd); BRDT (BD1): 2 nM (Kd); BRDT (BD2): 1 nM (Kd); CECR2: 570 nM (Kd)
Identity
Confirmed by NMR/HPLC/MS.
Applications
CF53 can be used to research the inhibition of the BET family of proteins in cancer therapy.
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