Properties
Description
dBET1, soluble in DMSO, water and ethanol, disrupts the function of proteins that recognize and bind specific epigenetic marks, affecting the interpretation of epigenetic signals. It targets BRD4 and Cereblon.
Molecular Formula
C38H37ClN8O7S
Targets
BRD4: 430 nM (EC50); Cereblon
Solubility
DMSO: 89 mg/mL (113.33 mM); Water: <1 mg/mL; Ethanol: 35 mg/mL (44.57 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
dBET1 can be used in research to degrade BRD4 and study the resulting cellular responses and therapeutic potential.
