Tipifarnib, soluble in DMSO and insoluble in water and ethanol, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting farnesyl transferase. The molecular weight of the compound is 489.4, and its molecular formula is C27H22Cl2N4O. It targets the FTase.
Molecular Weight
489.4
Molecular Formula
C27H22Cl2N4O
Targets
FTase
Form
Lyophilized powder
Purity
≥98%
Impurities
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.
Solubility
In vitro: DMSO: 14 mg/mL (28.6 mM); Water: insoluble; Ethanol: insoluble; In vivo: 15% Captisol + citrate vehicle, 4 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
Tipifarnib displays the significant potential to act as an effective farnesyltransferase inhibitor that prevents the farnesylation of proteins necessary for cell signaling and proliferation.
Publications
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Publications
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