Glyconanoparticle Physicochemical Property Characterization Service
Overview
Relying on the professional GlycoNano™ Platform, CD BioGlyco provides high-performance Glyconanoparticle Develpoment and Characterization services to meet the high demands of our clients. Characterization of glyconanoparticles is a critical step to ensure the success of their applications in biomedicine, drug delivery, environmental monitoring, and other fields. The characterization process is multifaceted and aims to analyze in detail the physical, chemical, and biological properties of glyconanoparticles. Moreover, our company offers a high-quality Glyconanoparticle Molecule Interaction Analysis Service.
Ensuring Glyconanoparticle Physicochemical Property Using Advanced Characterization Techniques
At CD BioGlyco, we have a variety of techniques to help our clients characterize glyconanoparticle physicochemical properties. Depending on the client's needs, we choose a single method or a combination of methods for glyconanoparticle characterization.
The technologies commonly used by our company include but are not limited to the elemental analyzer, hydrophobic interaction chromatography (HIC), X-ray photon spectroscopy, Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), Raman spectroscopy (RS), surface plasmon resonance (SPR), thermogravimetric analyze (TGA), small-angle neutron scattering (SANS), scanning electron microscopy (SEM), transmission electron microscopy, atomic force microscopy, and dark field microscopy.
Elemental Analyzer
HIC
XPS
FTIR
NMR
RS
SPR
TGA
Morphology
SANSOur company mainly provides testing services for the following characteristics:
- Morphology and size analysis: Our lab provides detailed morphology, size information, surface roughness, and 3D structure of glyconanoparticle surfaces. Moreover, we provide high-resolution images.
- Chemical composition analysis: Our lab provides analysis of functional groups, chemical bonds, atomic and molecular structure, and elemental composition.
- Crystal structure analysis: Our lab provides crystal structure and phase composition analysis of glyconanoparticles.
- Thermal analysis: Our lab provides thermogravimetric analysis and differential scanning calorimetry (DSC) is used to evaluate its thermal stability.
- Others: Our lab provides professional zeta potential measurement, viscosity, elasticity, and dynamic light scattering (DLS) analysis.
Workflow
Applications
- Glyconanoparticle physicochemical property characterization helps in assessing their stability, including dispersion, solubility, and chemical stability of the particles.
- Characterizing the particle size distribution, surface charge and morphology of glyconanoparticles can help to develop more stringent quality control standards to ensure the effectiveness and safety of drugs.
- Glyconanoparticle physicochemical property characterization helps to explore its possibilities in the development of new types of materials, such as for the preparation of biomedical materials, environmentally friendly materials, and functional materials.
Advantages of Us
- Our researchers have many years of operational experience in the characterization of glyconanoparticles, ensuring fast and accurate characterization.
- Our company offers a diverse range of characterization services to meet the different research needs of our clients.
- Our company has a professional data parsing team to help clients analyze and interpret each image.
Publication Data
Technology: Small-angle X-ray scattering (SAXS), X-ray diffraction (XRD), SANS, Cryo-(scanning) transmission electron microscopy (cryo-(S)TEM)
Journal: Journal of Controlled Release
Published: 2024
IF: 10.5
Results: In this study, the researchers performed an in-depth characterization of the two complexes, iron sucrose (IS) and ferric carboxymaltose (FCM), using a variety of techniques. The researchers used this orthogonal characterization to define the nanostructures, individual building blocks, and surface morphology of IS and FCM. Moreover, The FCM exhibits a localized carbohydrate shell around its core, and compared to IS, IS is characterized by a dispersed and dynamic carbohydrate ligand layer around its core. These findings contribute to a better understanding of the biological effects of iron-carbohydrate complexes.
Fig.1 SAXS data and model fits of IS and FCM. (Krupnik, et al., 2024)
Frequently Asked Questions
- How to test the stability of glyconanoparticles?
Our researchers measure particle size and polydispersity index (PDI) in different environments. For example, high temperature, low temperature, freezing, different pH, different storage times, and different solution concentrations. -
What are the features and benefits of XPS analysis?
The XPS method uses X-rays as an excitation source to analyze the surface elements of nanomaterials based on the characteristic energy distributions (energy spectra) of the electrons excited on their surfaces. Our researchers provide qualitative and semi-quantitative analyses of elements other than hydrogen and helium using X-ray photoelectron spectroscopy fingerprints. Moreover, the absolute sensitivity of XPS analysis is very high and the sample volume required for analysis is very small.
CD BioGlyco provides high-sensitivity glyconanoparticle physicochemical property characterization services. Our conscientious and responsible attitude has received praise from clients all over the world. We want to be your first choice in glyconanoparticle characterization. Feel free to contact us.
Reference
- Krupnik, L.; et al. Iron-carbohydrate complexes treating iron anaemia: understanding the nano-structure and interactions with proteins through orthogonal characterization. Journal of Controlled Release. 2024, 368: 566-579.
