HIF inhibitor 2-Methoxyestradiol, Purity ≥98%

Synonym: 362-07-2; HIF inhibitor; 2-ME2

MDL: MFCD00010489
CAS Number: 362-07-2
Compound CID: 66414

Product Size

10 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

MSDS

Properties

Description

2-Methoxyestradiol, soluble in DMSO and insoluble in ethanol and water, is designed to disrupt the hypoxia-inducible factor (HIF) pathway, aiming to hinder cancer cell survival and adaptation in low-oxygen environments characteristic of tumor growth. It targets HIF-1α (MDA-MB-231 cells), HIF-2α (Rat aortic smooth muscle A-10 cells), and HIF-2α (rat aortic smooth muscle A-10 cells).

Molecular Weight

302.4

Molecular Formula

C₁₉H₂₆O₃

Targets

HIF-1α (MDA-MB-231 cells); HIF-2α (Rat aortic smooth muscle A-10 cells); HIF-2α (Rat aortic smooth muscle A-10 cells)

Form

Lyophilized powder

Purity

Solubility

DMSO: 55 mg/mL (181.87 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

2-Methoxyestradiol is commonly researched for its effects on angiogenesis and tumor growth inhibition under hypoxic conditions.

Publications

Publications (0)

Publications

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