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Histone demethylases inhibitor GSK J1, Purity ≥98%
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Cat. No.: X24-05-ZQ372

Histone demethylases inhibitor GSK J1, Purity ≥98%

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Synonym: 1373422-53-7; GSK-J1; GSK J1; GSKJ1; 3-[[2-Pyridin-2-Yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-Yl)pyrimidin-4-Yl]amino]propanoic acid; Histone demethylases inhibitor

  • CAS Number: 1373422-53-7
  • Compound CID: 56963315
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Product Size
10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
GSK J1, soluble in DMSO and insoluble in ethanol and water, prevents the removal of methyl groups from histones, influencing gene expression by maintaining histone methylation. It targets JMJD3 (KDM6B) and UTX (KDM6A).
Molecular Weight
389.45
Molecular Formula
C22H23N5O2
Targets
JMJD3 (KDM6B): 28 nM; UTX (KDM6A): 53 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 70 mg/mL (179.74 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
GSK J1 is a selective Jumonji demethylase inhibitor used to study the impact of histone demethylation on gene expression.
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