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This complex material comprises hydroxycamptothecin chlorinated chitosan-coated nanoliposomes designed with a modified polymer-protected shell. The internal core consists of a phospholipid nanoliposome that accommodates the lipophilic alkaloid hydroxycamptothecin within its interior hydrocarbon core, while the external surface is modified by an electrostatic coating of the water-soluble cationic biopolymer chlorinated chitosan. This multi-layered architecture introduces a robust positive surface charge profile, increases the viscosity of the interfacial boundary, and establishes a mechanical barrier that prevents vesicle aggregation and minimizes drug leakage. The resulting composite nanoliposomes exhibit exceptional physical stability against crystallographic phase separation in open laboratory media.
Source
Custom synthesis
Functional Group
Hydroxycamptothecin; Chlorinated chitosan
Form
Solid or powder
Purity
≥95%
Impurities
No visible impurities to the naked eye.
Identity
HPLC/MS/NMR
Publications
Publications (0)
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Publications
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