Cat. No.: X24-09-YM341
IDO inhibitor, Epacadostat, Purity ≥98%
Synonym: 1204669-58-8; INCB 024360; Epacadostat (INCB024360); (Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine; INCB 24360; INCB-24360; 71596A9R13; N-(3-Bromo-4-fluoro-phenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine; N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide; N'-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboximidamide; IDO inhibitor
- MDL: MFCD29075639
- CAS Number: 1204669-58-8
- Compound CID: 135564890
Product Size
5 mg; 10 mg; 25 mg; 50 mg
Properties
Description
Epacadostat, soluble in DMSO and ethanol and insoluble in water, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting IDO. The molecular weight of the compound is 438.23, and its molecular formula is C11H13BrFN7O4S. It targets the IDO1.
Molecular Formula
C11H13BrFN7O4S
Impurities
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.
Solubility
In vitro: DMSO: 74 mg/mL (168.86 mM); Water: insoluble; Ethanol (warmed): 45 mg/mL; In vivo: 5% DMSO + 40% PEG 300 + 5% TWEEN 80 + 50 % ddH2O, 4.13 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
Epacadostat plays a key role in reversing the immunosuppressive environment created by tumors and boosting the immune system’s ability to attack cancer cells.
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