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LDE225
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Cat. No.: X23-12-YM460

LDE225

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Synonym: 956697-53-3; NVP-LDE225; Sonidegib

  • CAS Number: 956697-53-3
  • PubChem CID: 24775005
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Product Size
5 mg; 10 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
LDE225 (NVP-LDE225, sonidegib), soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets Smo (human) (cell-free assay), and Smo (mouse) (cell-free assay).
Molecular Weight
485.5
Molecular Formula
C26H26F3N3O3
Targets
Smo (Human) (Cell-free assay): 2.5 nM; Smo (Mouse) (Cell-free assay): 1.3 nM
Form
Lyophilized powder
Purity
>98%
Solubility
DMSO: 82 mg/mL (168.89 mM); Water: insoluble; Ethanol: 82 mg/mL (168.89 mM)
Applications
LDE225 (NVP-LDE225) can be used for its effect on inhibiting the Hedgehog signaling pathway, which is dysregulated in many cases of BCC.
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