LY 344864 hydrochloride inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets human 5-HT1A receptor, human 5-HT1B receptor, human 5-HT1D receptor, human 5-HT1E receptor, human 5-HT1F receptor, human 5-HT2A receptor, human 5-HT2B receptor, human 5-HT3A receptor, human 5-HT7 receptor, rat α1-adrenergic receptor, and rat α2-adrenergic receptor.
Molecular Weight
387.88
Molecular Formula
C21H23ClFN3O
Targets
Human 5-HT1A receptor: 0.530 μM; Human 5-HT1B receptor: 0.549 μM; Human 5-HT1D receptor: 0.575 μM; Human 5-HT1E receptor: 1.415 μM; Human 5-HT1F receptor: 0.006 μM; Human 5-HT2A receptor: 3.499 μM; Human 5-HT2B receptor: 1.695 μM; Human 5-HT3A receptor: 3.935 mM; Human 5-HT7 receptor: 4.851 μM; Rat α1-adrenergic receptor: 5.06 μM; Rat α2-adrenergic receptor: 3.69 μM
Form
Lyophilized powder
Purity
>98%
Applications
LY 344864 hydrochloride can be used to research and develop therapeutic strategies for certain diseases that involve excessive activation of GPCR-G protein signaling pathways.
Publications
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Publications
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