(S)-Crizotinib, soluble in warmed DMSO and ethanol and insoluble in water, is an effective DNA damage inhibitor, that has the ability to prevent the pathway of DNA damage by inhibiting MTH1. It targets the MTH1 (cell-free assay).
Molecular Weight
450.34
Molecular Formula
C21H22Cl2FN5O
Targets
MTH1 (Cell-free assay): 72 nM
Form
Lyophilized powder
Purity
≥98%
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
(S)-Crizotinib is a DNA damage inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of non-small cell lung cancer (NSCLC) and other cancers with ALK (anaplastic lymphoma kinase) or ROS1 (c-ros oncogene 1) gene rearrangements.
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