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NADPH oxidase inhibitor GKT137831, Purity ≥98%
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Cat. No.: X23-10-ZQ603

NADPH oxidase inhibitor GKT137831, Purity ≥98%

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Synonym: 1218942-37-0; GKT137831; Setanaxib; GKT-137831; 2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione; NADPH oxidase inhibitor

  • MDL: MFCD27923122
  • CAS Number: 1218942-37-0
  • Compound CID: 58496428
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
GKT137831, soluble in warmed DMSO and insoluble in water and ethanol, is a NADPH oxidase inhibitor. It targets NOX1 and NOX4.
Molecular Weight
394.85
Molecular Formula
C21H19ClN4O2
Targets
NOX1: 110 nM (Ki); NOX4: 140 nM (Ki)
Form
Lyophilized powder
Purity
≥98%
Solubility
Warmed DMSO: 72 mg/mL (182.34 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
GKT137831 can be used to study its selective inhibition of NOX1/4 in fibrosis and vascular diseases.
Publications
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