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PARP inhibitor Olaparib, Purity ≥98%
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Cat. No.: X23-10-ZQ230

PARP inhibitor Olaparib, Purity ≥98%

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Synonym: 763113-22-0; Olaparib; Lynparza; AZD2281; KU-0059436; AZD-2281; AZD 2281; 4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one; PARP inhibitor

  • MDL: MFCD13185161
  • CAS Number: 763113-22-0
  • Compound CID: 23725625
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Product Size
10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Olaparib, soluble in warmed DMSO and water and insoluble in ethanol, binds to the PARP enzyme's active site, preventing it from repairing single-strand DNA breaks. It targets PARP2, PARP1, and Tankyrase-1.
Molecular Weight
434.5
Molecular Formula
C24H23FN4O3
Targets
PARP2: 1 nM; PARP1: 5 nM; Tankyrase-1: 1.5 nM
Form
Lyophilized powder
Purity
≥98%
Solubility
Warmed DMSO: 74 mg/mL (170.32 mM); Water: <1 mg/mL; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Olaparib can be used to investigate its effects as a PARP inhibitor in BRCA-mutated cancers.
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