Cat. No.: X24-08-YM008
PARP inhibitor, RK-287107, Purity ≥98%
Synonym: 2171386-10-8; RK287107; RK 287107; 2-[4,6-Difluoro-1-(2-hydroxyethyl)spiro[2H-indole-3,4'-piperidine]-1'-yl]-5,6,7,8-tetrahydro-3H-quinazolin-4-one
- CAS Number: 2171386-10-8
- Compound CID: 137701512
Product Size
5 mg; 10 mg; 50 mg; 100 mg
Properties
Description
RK-287107, soluble in DMSO, water and ethanol, is an effective DNA damage inhibitor, that has the ability to prevent the pathway of epigenetics by inhibiting PARP. It targets the tankyrase-1 and tankyrase-2.
Molecular Formula
C22H26F2N4O2
Targets
Tankyrase-1: 14.3 nM (IC50); Tankyrase-2: 10.6 nM (IC50)
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: 81 mg/mL (194.49 mM); Water: <1 mg/mL; Ethanol: <1 mg/mL
Applications
RK-287107 is an epigenetic inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of cancers and inflammatory diseases by disrupting the NF-κB signaling pathway, which plays a role in promoting cell survival and proliferation.
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