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PDK1 inhibitor BX-912, Purity ≥98%
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Cat. No.: X24-05-ZQ219

PDK1 inhibitor BX-912, Purity ≥98%

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Synonym: 702674-56-4; BX912; PDK1 inhibitor

  • CAS Number: 702674-56-4
  • Compound CID: 11754511
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Product Size
5 mg; 10 mg; 50 mg; 100 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
BX-912, soluble in DMSO and ethanol and insoluble in water, is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells. It targets KDR, PKA, c-Kit, CDK2/CyclinE, Chk1, EGFR, GSK-3β, InsulinReceptor, PDK-1, PKC, and T-Fyn.
Molecular Weight
471.4
Molecular Formula
C20H23BrN8O
Targets
KDR: 410 nM; PKA: 110 nM; c-Kit: 850 nM; CDK2/CyclinE: 650 nM; Chk1: 830 nM; EGFR: >10 μM; GSK-3β: 7.4 μM; InsulinReceptor: 6.1 μM; PDK-1: 12 μM; PKC: 1.25 μM; T-Fyn: 2.1 μM
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 80 mg/mL (169.72 mM); Water: Insoluble; Ethanol: 80 mg/mL (169.72 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
BX-912 is used to inhibit PDK1 activity, assisting in the exploration of PI3K/AKT signaling in cancer.
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