Xylan-pemetrexed conjugation represents a modern pharmaceutical approach, combining the antifolate drug's characteristics with xylan's β-1,4-linked xylose chains from agricultural byproducts. This combination improves solution behavior through the polysaccharide's hydration capacity.
Glycan Name
Xylan
Glycan Structure
Its glycan structure is a linear backbone of β-1,4-linked D-xylose residues with side-chain substitutions including α-linked arabinofuranose, glucuronic acid/4-O-methyl-glucuronic acid, and acetyl groups at O-2 or O-3 positions.
Source
Chemical synthesis
Functional Group
Pemetrexed
Form
Solid or powder
Purity
≥95%
Impurities
No visible impurities to the naked eye.
Solubility
This product is soluble in most organic solvents, such as DCM, DMF, DMSO, and THF, and exhibits excellent solubility in water.
Identity
Confirmed by NMR.
Applications
Xylan-pemetrexed can be used for its potential to create modular assembly platforms using high-affinity protein-ligand bridging strategies.
Publications
Publications (0)
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Publications
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