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Prucalopride
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Cat. No.: X23-12-YM599

Prucalopride

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Synonym: 179474-81-8; Motegrity; Resotrans

  • CAS Number: 179474-81-8
  • Compound CID: 3052762
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Product Size
5 mg; 10 mg; 25 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Prucalopride, soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets 5-HT3, 5-HT4B, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT4A.
Molecular Weight
367.9
Molecular Formula
C18H26ClN3O3
Targets
5-HT3: 3.822 μM; 5-HT4B: 8 nM; 5-HT1A: >10 μM; 5-HT1B: >10μM; 5-HT1D: >10 μM; 5-HT1E: >10μM; 5-HT1F: >10 μM; 5-HT2A: >10 μM; 5-HT2B: >10 μM; 5-HT2C: >10 μM; 5-HT4A: 2.5 nM
Form
Lyophilized powder
Purity
>98%
Solubility
DMSO: 52 mg/mL (141.35 mM); Water: insoluble; Ethanol: 33 mg/mL (89.7 mM)
Applications
Prucalopride can be used for its effect on improving symptoms of constipation, such as infrequent bowel movements and difficulty passing stools.
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