Properties
Description
Raltitrexed-chondroitin sulfate prodrug formulation demonstrates covalent tethering of the antimetabolite to chondroitin's polysaccharide chain through hydrolytically stable bonds for controlled drug release.
Glycan Name
Chondroitin sulfate
Glycan Structure
The glycan structure of chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) composed of repeating disaccharide units. Each unit consists of:
N-acetyl-D-galactosamine (GalNAc) (β1→4 linked)
D-glucuronic acid (GlcA) (β1→14 linked)
Source
Chemical synthesis
Functional Group
Raltitrexed
Impurities
No visible impurities to the naked eye.
Solubility
This product is soluble in most organic solvents, such as DCM, DMF, DMSO, and THF, and exhibits excellent solubility in water.
Identity
Confirmed by NMR.
Applications
Chondroitin sulfate-raltitrexed can be used for its potential to study folate antagonist conjugates for colorectal cancer cell inhibition.
