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Raltitrexed pH-sensitive liposomes

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Cat. No.: X26-05-ZQ2898

Raltitrexed pH-sensitive liposomes

Name: Raltitrexed pH-sensitive liposomes
SKU: X26-05-ZQ2898

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Synonym: Raltitrexed pH-sensitive LPs; Raltitrexed pH-responsive liposomes; Raltitrexed acid-sensitive liposomal nanoparticles

Product Size

100 mg; 250 mg; 500 mg; 1 g; 5 g

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

This advanced engineered responsive system features a quinazoline folate analogue loaded within pH-sensitive liposomes. The vesicular matrix encapsulates the water-soluble quinazoline derivative raltitrexed within its central aqueous reservoir, utilizing a specialized combination of dioleoylphosphatidylethanolamine and an amphiphilic stabilizer (such as cholesteryl hemisuccinate) designed to undergo lateral phase separation under specific environmental triggers. Under neutral laboratory calibration indices, the bilayer remains highly stable; however, crossing an acidic pH threshold triggers rapid protonation of the stabilizer, inducing an immediate gel-to-inverted-hexagonal phase transition that causes instantaneous membrane destabilization and raltitrexed cargo release.

Source

Custom synthesis

Functional Group

Raltitrexed; pH-sensitive lipid matrix

Form

Solid or powder

Purity

≥95%

Impurities

No visible impurities to the naked eye.

Identity

HPLC/MS/NMR

Publications

Publications (0)

Publications

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Publications

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