Semagacestat (LY450139), soluble in DMSO and ethanol and insoluble in water, inhibits the activity of proteases, which are enzymes involved in the breakdown of proteins. It targets γ secretase(Aβ38) (H4 human glioma cells), γ secretase(Aβ40) (H4 human glioma cells), γ secretase(Aβ42) (H4 human glioma cells), and notch (H4 human glioma cells).
Molecular Weight
361.4
Molecular Formula
C19H27N3O4
Targets
γ Secretase (Aβ38) (H4 human glioma cells): 12.0 nM; γ Secretase (Aβ40) (H4 human glioma cells): 12.1 nM; γ Secretase(Aβ42) (H4 human glioma cells): 10.9 nM; Notch (H4 human glioma cells): 14.1 nM
Semagacestat (LY450139) can be studied for its inhibitory effct on Alzheimer's disease.
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