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Semagacestat

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Cat. No.: X23-12-YM098

Semagacestat

Synonym: 425386-60-3; LY-450139

CAS Number: 425386-60-3
PubChem CID: 9843750

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

Semagacestat (LY450139), soluble in DMSO and ethanol and insoluble in water, inhibits the activity of proteases, which are enzymes involved in the breakdown of proteins. It targets γ secretase(Aβ38) (H4 human glioma cells), γ secretase(Aβ40) (H4 human glioma cells), γ secretase(Aβ42) (H4 human glioma cells), and notch (H4 human glioma cells).

Molecular Weight

361.4

Molecular Formula

C₁₉H₂₇N₃O₄

Targets

γ Secretase (Aβ38) (H4 human glioma cells): 12.0 nM; γ Secretase (Aβ40) (H4 human glioma cells): 12.1 nM; γ Secretase(Aβ42) (H4 human glioma cells): 10.9 nM; Notch (H4 human glioma cells): 14.1 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 66 mg/mL (182.6 mM); Water: insoluble; Ethanol: 38 mg/mL (105.13 mM)

Applications

Semagacestat (LY450139) can be studied for its inhibitory effct on Alzheimer's disease.

Publications

Publications (0)

Publications

Publications

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