SKI-II, soluble in DMSO and ethanol and insoluble in water, targets and inhibits the activity of sphingosine kinase enzymes, which play a crucial role in the sphingolipid metabolic pathway. It targets S1P receptor.
SKI-II is used as a non-specific SphK inhibitor to study sphingolipid metabolism and its impact on cancer cell viability and drug resistance.
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