R935788, soluble in warmed DMSO and insoluble in water and ethanol, blocks the activity of spleen tyrosine kinase (Syk), a key protein involved in the signaling pathways of various immune cells and implicated in the pathogenesis of autoimmune diseases and certain cancers. It targets Syk.
R935788 inhibits tumor growth in the mouse model by blocking antigen-dependent B-cell receptor signaling.
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