Technologies for Polysaccharide Conjugation

Different Polysaccharides Have a Variety of Conjugation Opportunities

Polysaccharides are harmless and biocompatible natural substances. As a result, they're commonly utilized in medication delivery and other scientific studies. A bioactive substance is covalently attached to the polysaccharide backbone, either directly or through the use of a linker. Polysaccharides have a wide variety of molecular weights and a large number of functional groups that can be chemically modified. The manner of conjugation is determined by the functional groups accessible on the medication and the polymer. To connect the two, synthetic modification may be used. Linkers are utilized instead if such compatibility is not available. The linkers connect the polymer to the target molecule. The most basic polysaccharide molecules are made up of monosaccharide repeating units with just hydroxyl groups as functional groups (cellulose, starch, pullulan, arabinogalactan). The amino sugars chitin/chitosan provide chances for amine conjugation. The polysaccharide employed as an amine is seen in the image below.

Fig.1 Chemical modifications where the polysaccharide is used as an amine (mainly chitosan). (Basu, et al., 2015)

Polysaccharide Conjugation Services at CD BioGlyco

Polysaccharides containing amine, carboxylic acid, and aldehyde activity are commonly utilized in conjugations. Most bioactive molecules (drugs, proteins, and nucleic acids) are easier to conjugate using typical reaction conditions or "click chemistry". CD BioGlyco has built an outstanding and top-notch lab and established an excellent production and analysis platform for clients.

Fig.2 Breif of chemical methods used for conjugation. (CD BioGlyco)

For chemical-based conjugation, polysaccharides can be used as alcohol, amine, carboxylic acid, and so on. Based on the several groups, CD BioGlyco offers chemical-based custom conjugation services. Besides the chemical-based conjugation, CD BioGlyco also provides physical crosslinking-based polysaccharide conjugation services including Ionic crosslinking-based and thermogelation-based conjugation.

Applications of Polysaccharide Conjugation

• This technology has applications in tissue engineering, where polysaccharide conjugates are used to promote cell growth and tissue regeneration.
• Polysaccharide conjugations enable the targeted delivery of therapeutic agents, improving drug efficacy and reducing side effects.
• Polysaccharide conjugations are utilized in gene delivery systems to improve the stability and transfection efficiency of genetic materials.

Advantages of Us

• Our analytical platform provides a wide range of high-quality, excellent, and suitable custom services for our clients, especially chemistry-based and physical crosslinking-based services.
• Our talented scientists and well-experienced laboratory team can perform analytical experiments and subsequent data analysis in good quality, providing our clients with reliable laboratory reports.
• Our service team is available to respond to inquiries from clients around the world promptly.

CD BioGlyco is a company with extensive glycan chemistry research experience and aims to be clients' best glycan research cooperator. Our research and service team provides professional and custom conjugation and analysis services for our clients. If you have any questions or require details information, please feel free to contact us.

Reference:

1. Basu, A.; et al. Polysaccharide-based conjugates for biomedical applications. Bioconjugate Chemistry. 2015, 26(8): 1396–1412.