The Physiological Role of UDP

Uridine 5'-diphosphate (UDP) is an organic compound of pyrimidine ribonucleoside diphosphate, which consists of a pyrophosphate group, pentose ribose sugar, and nucleobase uracil. UDP can be used as a signaling molecule between cells to participate in the signal transduction process. In the process of the cellular respiratory chain and adenosine triphosphate (ATP) generation, UDP can be interconverted with glucose and provide energy by participating in glycolysis and gluconeogenesis. UDP is a form of nucleotide diphosphate, which can be used as one of the substrates for RNA and DNA synthesis, supplying bases in nucleic acid structures by participating in the nucleotide synthesis pathway. In addition, UDP can also be used as a substrate and an activator to participate in the synthesis, modification, and degradation of carbohydrates.

Fig.1 The structure of UDP. (PubChem)

UDP Production Services at CD BioGlyco

CD BioGlyco supplies various types of UDP products.

• UDP Standards

High-purity, quantified UDP standards are typically supplied in powder or solution form for laboratory research and calibration.

• Uridine
• Uridine monophosphate (UMP)
• UDP
• Uridine triphosphate (UTP)

• UDP Derivatives

CD BioGlyco provides various derivatives formed by combining UDP with specific sugar groups.

• UDP glucose
• UDP galactose
• UDP glucuronic acid (UDP-GlcA)
• UDP glucosamine (UDPGA)
• UDP-D-galactose disodium salt
• UDP-D-glucuronide trisodium salt
• UDP-2-deoxy-2-fluoro-D-glucose sodium salt
• Recombinant UDP glucuronosyltransferase 1 family
• Polypeptide A1 (UGT1A1)

• Antibodies and Antigens

CD BioGlyco provides antibodies and antigens products of GDP, which create an immune response against UDP or UDP-related molecules and are helpful in immunological research and diagnostic testing.

• The complete antigen of UDP
• A monoclonal antibody to UDP
• Polyclonal antibody to UDP

• Enzyme Kits

CD BioGlyco provides kits that provide UDP-related enzymes and their substrates for measuring UDP-metabolizing enzyme activities or related biochemical indicators. It can be applied to medical diagnosis, drug screening, and metabolic pathways.

• CLIA kit for UDP
• ELISA kit for UDP
• UDP-glucose (UGlc) ELISA kit
• UDP glucuronide (UGlu) ELISA kit
• UDP-glucuronosyltransferase (UGT) ELISA kit
• UDP-glucose glycoprotein glycosyltransferase 1 (UGGT1) ELISA kit
• UDP-N-acetylglucosamine(UDP-GlcNAc) ELISA kit
• UDP-galactose-4-epimerase (GALE) ELISA kit
• UDP glucose ceramide glucosyltransferase (UGCG) detection kit
• UDP-glucose pyrophosphorylase (UDPase) kit

Moreover, CD BioGlyco provides a customized synthesis of products, purification, separation, and quality testing services, including Adenosine Diphosphate (ADP) , Cytidine Diphosphate (CDP), Guanosine Diphosphate (GDP), and UDP.

Fig.2 UDP production services. (CD BioGlyco)

Applications

• Chemical research: UDP can be used as substrates or intermediates in chemical synthesis reactions for the construction of glycosylation reagents, enzyme substrates, and synthesis of sugar compounds to form molecules with specific activities or functions. It can participate in various glycosylation reactions, carbohydrate synthesis, and modification reactions.
• Biological research: UDP and its derivatives can be used in molecular biology experiments, such as enzyme activity determination, metabolic pathway research, enzyme-substrate screening, etc. UDP can also be used as a substrate or intermediate product in microbial fermentation processes.
• Drug development: Studying the interaction between UDP and specific receptors, enzymes or regulators can help in drug target screening and drug design.
• Medical testing: UDP-related enzyme activity or metabolites can be measured using specific enzyme kits to detect genetic metabolic diseases or other UDP-related diseases.
• Food industry: UDP is widely used in the food industry as an additive to adjust the sweetness, texture, and stability of products.

Advantages

• High purity and stability: The UDP products have undergone strict quality control and verification, and can maintain their activity and function during storage and use, with high purity and good stability.
• Quantifiable and standardized: UDP products are typically supplied in known concentrations, which can be precisely quantified as needed.
• Diversity and flexibility: Various forms of UDP and its derivatives are provided. This diversity makes it possible to meet the needs of different research or applications.

CD BioGlyco provides comprehensive UDP production services. Please feel free to contact us in time if you need to obtain UDP production service, we are your best choice.