Properties
Description
2-Deoxy-2,2-difluoro-D-ribose is a ribose analog lacking a hydroxyl group and containing two fluorine atoms at the C2 position, expected to be water-soluble and potentially useful in the synthesis of modified nucleic acid components with altered stability.
Source
Chemical synthesis
Solubility
2-Deoxy-2,2-difluoro-D-ribose is soluble in water and organic solvents such as DCM, DMF, and DMSO.
Identity
Confirmed by MS/NMR.
Applications
2-Deoxy-2,2-difluoro-D-ribose, a geminally difluorinated deoxyribose analog, can be incorporated into DNA analogs to enhance their stability and resistance to nucleases.
