Biomedical Applications of Biodegradable Carboxymethylated Chitosan

The insolubility of chitosan in water and common organic solvents limits its extensive research and application in many fields such as biomedicine. Therefore, increasing the water solubility of chitosan through degradation and modification and improving its antibacterial and bacteriostatic activity has become an important direction of chitosan research. Carboxymethylation of chitosan was shown to help surmount this hurdle. The introduction of -COOH significantly improved the water solubility of chitosan, and the coexistence of -COOH and -NH₂ groups made chitosan have better biocompatibility, moisture absorption, and moisture retention, antibacterial properties, etc., which greatly expanded the value and application scope of chitosan.

Carboxymethyl chitosan is an important water-soluble chitosan derivative with many medical effects, such as promoting wound healing, hemostasis, scar inhibition, analgesia, and bacteriostasis. Carboxymethyl chitosan has good biocompatibility and biodegradability and is widely used in hydrogel and wound healing biomaterials and tissue engineering matrix materials. Furthermore, carboxymethyl chitosan is easily processed into nanoparticles, making it more suitable for drug delivery, biosensors, and gene therapy.

Fig.1 The chemical structures of chitosan and carboxymethyl chitosan derivatives. (Shariatinia, 2018)

Biodegradable Carboxymethylated Chitosan Development Services at CD BioGlyco

Our R&D team is committed to providing clients with professional and reasonable solutions to develop Chitosan-based Biodegradable Materials including biodegradable carboxymethylated chitosan. Our services include but are not limited to:

• Synthesis of carboxymethyl chitosan
  We provide clients with a variety of synthetic methods including direct alkylation, reductive alkylation, and Michael addition to help clients prepare N-carboxymethyl chitosan (NCMC), O-carboxymethyl chitosan (OCMC) and N,O-carboxymethyl chitosan (NOCMC).
• Characterization of carboxymethyl chitosan
  We help clients characterize the physical and chemical properties of carboxymethyl chitosan by methods such as FTIR spectroscopy, ¹H NMR spectroscopy, ¹³C NMR spectroscopy, differential scanning calorimetry, titrimetry, viscometry, gel permeation chromatography, X-ray diffraction, and capillary zone electrophoresis.
• Modification of carboxymethyl chitosan
  We provide our clients with further modifications of carboxymethyl chitosan to obtain derivatives as amphiphilic, quaternized, or grafted by acylation, alkylation, or grafting.
• Antioxidant, antibacterial, and apoptosis inhibitory activity analysis of carboxymethyl chitosan.

Applications

• Targeted drug delivery and enzyme delivery
• Tissue engineering and wound healing
• DNA delivery
• Permeation enhancer
• Bioimaging

As a leading Polysaccharide-based Biodegradable Materials supplier and manufacturer, CD BioGlyco provides professional and complete solutions to help clients develop high-quality biodegradable carboxymethylated chitosan. We offer multiple techniques to further characterize it and implement additional measures to further establish reproducibility and consistency.

If you are interested in our business, please feel free to contact us for more details, and we will respond promptly.