Cat. No.: X24-06-ZQ417
BTK inhibitor AVL-292, Purity ≥98%
Synonym: 1202757-89-8; BTK inhibitor; AVL292; AVL 292; CC292; CC-292; CC 292
- MDL: MFCD25976876
- CAS Number: 1202757-89-8
- Compound CID: 59174488
Product Size
5 mg; 10 mg; 25 mg; 50 mg
Properties
Description
AVL-292, soluble in DMSO and insoluble in ethanol and water, is a compound designed to block Bruton’s tyrosine kinase (BTK), an enzyme essential for the proliferation and survival of certain cancerous B cells. It targets c-Src, YES, BRK, BTK, CSK, Fyn, Hck, LCK, and Lyn.
Molecular Formula
C22H22FN5O3
Targets
c-Src: 1.729 μM; YES: 723 μM; BRK: 2.43 μM; BTK: <0.5 nM; CSK: <0.5 nM; Fyn: 7.146 μM; Hck: 14.46 μM; LCK: 9.079 μM; Lyn: 4.401 μM
Solubility
DMSO: 78 mg/mL (184.2 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
AVL-292 is applied to study the inhibition of Bruton’s tyrosine kinase in B-cell-mediated diseases, contributing to drug development for conditions like leukemia and lymphoma.
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