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CFTR inhibitor VX-809, Purity ≥98%
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Cat. No.: X24-07-ZQ309

CFTR inhibitor VX-809, Purity ≥98%

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Synonym: 936727-05-8; CFTR inhibitor; VX809

  • MDL: MFCD16659051
  • CAS Number: 936727-05-8
  • Compound CID: 16678941
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Product Size
5 mg; 10 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
VX-809, soluble in DMSO and ethanol and insoluble in water, blocks the activity of the cystic fibrosis transmembrane conductance regulator protein, which plays a crucial role in the movement of chloride ions across cell membranes. It targets F508del-CFTR (Fisher rat thyroid cells).
Molecular Weight
452.4
Molecular Formula
C24H18F2N2O5
Targets
F508del-CFTR (Fisher rat thyroid cells): 0.1 μM (EC50)
Form
Lyophilized powder
Purity
≥98%
Solubility
DMSO: 88 mg/mL (194.51 mM); Water: Insoluble; Ethanol: 6 mg/mL (13.26 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
VX-809 (Lumacaftor) is employed in studies as a CFTR corrector to investigate therapeutic strategies for cystic fibrosis by correcting the folding defect of mutant CFTR protein.
Publications
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