Cat. No.: X24-08-YM090
DNA-RNA synthesis inhibitor, CX-5461, Purity ≥98%
Synonym: 1138549-36-6; CX5461; 2-(4-Methyl-1,4-diazepan-1-yl)-N-[(5-methylpyrazin-2-yl)methyl]-5-oxo-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide
- CAS Number: 1138549-36-6
- Compound CID: 25257557
Product Size
5 mg; 10 mg; 50 mg; 100 mg
Properties
Description
CX-5461, soluble in DMSO and warmed ethanol and insoluble in water, is an effective DNA damage inhibitor, that has the ability to prevent the pathway of DNA damage by inhibiting DNA-RNA synthesis. It targets the A375, HCT-116, MIA PaCa-2, and Pol I-driven transcription of rRNA (HCT-116, A375, MIA PaCa-2 cells).
Molecular Formula
C27H27N7O2S
Targets
A375: 58 nM (ED50); HCT-116: 167 nM (ED50); MIA PaCa-2: 74 nM (ED50); Pol I-driven transcription of rRNA (HCT-116, A375, MIA PaCa-2 cells): 142 nM
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: <1 mg/mL; Water: insoluble; DMF (warmed): 3 mg/mL (5.84 mM)
Applications
CX-5461 is a DNA damage inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of cancer, especially after cancer stem cells have been sensitized to chemotherapy.
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