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EGFR-HER2 inhibitor AV412, Purity ≥98%
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Cat. No.: X23-10-ZQ619

EGFR-HER2 inhibitor AV412, Purity ≥98%

Synonym: 451492-95-8; AV-412 free base; AV-412 (free base); MP-412 free base; N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide; MP-412; N-[4-(3-Chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide; EGFR-HER2 inhibitor

  • MDL: MFCD16038939
  • CAS Number: 451492-95-8
  • Compound CID: 9806229
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Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Price
Datasheet
MSDS
Properties
Description
AV412 is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, EGFR (L858R), EGFR (L858R/T790M), EGFR (T790M), and ErbB2.
Molecular Weight
507.02
Molecular Formula
C27H28ClFN6O
Targets
EGFR: 0.75 nM; EGFR (L858R): 0.5 nM; EGFR (L858R/T790M): 2.3 nM; EGFR (T790M): 0.79 nM; ErbB2: 19 nM
Form
Lyophilized powder
Purity
≥98%
Identity
Confirmed by NMR/HPLC/MS.
Applications
AV412 is primarily used to investigate the inhibition of EGFR-mediated signaling pathways in cancer research.
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